Recombination of polynucleotide sequences using random or defined primers
- Filed
- 4 August 1997
- Granted
- 28 November 2000
- Assignee
- California Institute of Technology
- Co-inventors
- Zhixin Shao, Joseph A. Affholter, Huimin H. Zhao, Lorraine J. Giver
Chemical engineering and biochemistry
Frances H. Arnold: inventions and patents
Known for Directed evolution of enzymesNationality Born in Pittsburgh, Pennsylvania, United StatesBorn 25 July 1956
Frances H. Arnold, born in Pittsburgh, received half of the 2018 Nobel Prize in Chemistry for the directed evolution of enzymes. She was at the California Institute of Technology at the time of the award. She is the first named inventor on US Patent 6,153,410, assigned to Caltech, and was inducted into the National Inventors Hall of Fame in 2014.1,2,3
Patents
Inventions
- Directed evolution of enzymes. A laboratory method that evolves enzymes towards useful traits by mutating and recombining their DNA and screening the results, as described by the National Inventors Hall of Fame.3,1
Recognition
- 2014 Inducted into the National Inventors Hall of Fame3
- 2018 Nobel Prize in Chemistry (one half), for the directed evolution of enzymes1
Sources
- Nobel Prize Outreach, Frances H. Arnold, Facts, 2018 (accessed 2026-10-27)
- Google Patents, US6153410A Recombination of polynucleotide sequences using random or defined primers (accessed 2026-10-27)
- National Inventors Hall of Fame, Frances Arnold (accessed 2026-10-27)